State television said the attacker set off an explosive belt at a bus station in the southwest of the city.
The governor of Hama said the explosion killed two women, according to another state-run channel, Ikhbariya. It had quoted him earlier as saying three people had died.
On Sunday, a bomb killed 20 people and wounded dozens more in Damascus.
Since the start of the year, a string of blasts have hit the cities of Damascus and Homs, which are under the control of President Bashar al-Assad’s government fighting rebel groups in the country’s six-year war.