16 inmates has been killed in a rival gang fight, Guatemalan prison officials reported.
Police have not yet been able to retake control of the prison in the town of Escuintla, about 60km (37
miles) south of the capital, Guatemala City.
Officials said they would wait for reinforcements before entering the jail as the security forces were
currently outnumbered four-to-one by the rioters.
The jail is notorious for overcrowding and violence.
More than 3,000 prisoners are held at the jail, which was built to house just 600.
About 2,300 inmates are currently engaged in a stand-off with 500 members of the security forces,
Deputy Interior Minister Elmer Sosa said.
The minister confirmed that some of the inmates had guns.
Mr Sosa said that there were conflicting theories as to what had triggered the violence.
He said there were reports that convicted gang members had clashed with inmates without any
gang affiliation after visiting hours on Sunday.
Local media are reporting that the inmates may be holding a number of visitors hostage.
However, Mr Sosa said another possibility was that inmates had turned violent after guards had foiled an attempted prison break.
Earlier this year, guards scuppered another escape attempt when they discovered a tunnel underneath
The exact number of people injured in Sunday’s fight is not yet known, emergency workers at the scene said.
Members of violent street gangs make up the bulk of Guatemala’s prison population and deadly gang
warfare inside prison walls is not uncommon.
Severe overcrowding makes it hard for guards to control the prisoners – who are often heavily armed
with home-made weapons as well as firearms smuggled into the jail.